Corpus ID: 11712276

Small Molecule Induction of Human Umbilical Stem Cells into MBP-positive Oligodendrocytes in a Defined Three-Dimensional Environment.

@article{Davis2012SmallMI,
  title={Small Molecule Induction of Human Umbilical Stem Cells into MBP-positive Oligodendrocytes in a Defined Three-Dimensional Environment.},
  author={Hedvika Davis and Xiufang Guo and S. Lambert and Maria Stancescu and James J. Hickman},
  journal={ACS chemical neuroscience},
  year={2012},
  volume={3 1},
  pages={
          31-39
        }
}
  • Hedvika Davis, Xiufang Guo, +2 authors James J. Hickman
  • Published in ACS chemical neuroscience 2012
  • Medicine
  • Stem cells from umbilical cord would be a favorable alternative to embryonic stem cells for therapeutic applications. In this study, human multipotent progenitor cells (MLPCs) from umbilical cord were differentiated into oligodendrocytes by exposure to a range of microenvironmental chemical and physical cues. Chemical cues were represented by a novel defined differentiation medium containing the neurotransmitter norepinephrine (NE). In traditional 2 dimensional (2D) conditions, the MLPCs… CONTINUE READING

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