Small Molecule AKAP-Protein Kinase A (PKA) Interaction Disruptors That Activate PKA Interfere with Compartmentalized cAMP Signaling in Cardiac Myocytes*

@inproceedings{Christian2011SmallMA,
  title={Small Molecule AKAP-Protein Kinase A (PKA) Interaction Disruptors That Activate PKA Interfere with Compartmentalized cAMP Signaling in Cardiac Myocytes*},
  author={Frank Christian and M{\'a}rta Szasz{\'a}k and Sabine Friedl and Stephan Drewianka and Dorothea Lorenz and Andrey C. da Costa Goncalves and Jens Furkert and C Gloria Vargas and Peter Schmieder and Frank Goetz and Kerstin Z{\"u}hlke and Marie Christine Moutty and Hendrikje G{\"o}ttert and Mangesh Joshi and Bernd Reif and Hannelore Haase and Ingo Morano and Solveig Grossmann and Anna Klukovits and Judit Verli and R{\'o}bert G{\'a}sp{\'a}r and Claudia Noack and Martin W Bergmann and Robert S. Kass and Kornelia Hampel and Dmitry Kashin and Hans-Gottfried Genieser and Friedrich W Herberg and Debbie Willoughby and Dermot M. F. Cooper and George S Baillie and Miles D Houslay and Jens Peter von Kries and Bastian Zimmermann and Walter Rosenthal and Enno Klussmann},
  booktitle={The Journal of biological chemistry},
  year={2011}
}
A-kinase anchoring proteins (AKAPs) tether protein kinase A (PKA) and other signaling proteins to defined intracellular sites, thereby establishing compartmentalized cAMP signaling. AKAP-PKA interactions play key roles in various cellular processes, including the regulation of cardiac myocyte contractility. We discovered small molecules, 3,3'-diamino-4,4'-dihydroxydiphenylmethane (FMP-API-1) and its derivatives, which inhibit AKAP-PKA interactions in vitro and in cultured cardiac myocytes. The… CONTINUE READING

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A-kinase anchoring proteins: scaffolding proteins in the heart.

American journal of physiology. Heart and circulatory physiology • 2011
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