Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aβ-Induced Neurodegeneration and Synaptic Impairment

@article{Yang2008SmallMN,
  title={Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aβ-Induced Neurodegeneration and Synaptic Impairment},
  author={Tao Yang and Juliet K. Knowles and Qun Lu and Hong Zhang and Ottavio Arancio and Laura A. Moore and Timothy Chang and Qian Wang and Katrin Andreasson and Jayakumar Rajadas and Gerald G. Fuller and Youmei Xie and Stephen M Massa and Frank M Longo},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={654 - 60}
}
The p75 neurotrophin receptor (p75(NTR)) is expressed by neurons particularly vulnerable in Alzheimer's disease (AD). We tested the hypothesis that non-peptide, small molecule p75(NTR) ligands found to promote survival signaling might prevent Abeta-induced degeneration and synaptic dysfunction. These ligands inhibited Abeta-induced neuritic dystrophy, death of cultured neurons and Abeta-induced death of pyramidal neurons in hippocampal slice cultures. Moreover, ligands inhibited Abeta-induced… CONTINUE READING

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The p75 neurotrophin receptor: at the crossroad of neural repair and death

  • Neural regeneration research
  • 2015
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 49 REFERENCES

Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2006
VIEW 18 EXCERPTS

In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis

WB JrStine, KN Dahlgren, GA Krafft, MJ LaDu
  • J Biol Chem
  • 2003
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Small molecule modulation of p75 neurotrophin receptor functions.

  • CNS & neurological disorders drug targets
  • 2008
VIEW 2 EXCERPTS