Small Intestinal Glucose Delivery Affects the Lowering of Blood Glucose by Acute Vildagliptin in Type 2 Diabetes.

@article{Wu2016SmallIG,
  title={Small Intestinal Glucose Delivery Affects the Lowering of Blood Glucose by Acute Vildagliptin in Type 2 Diabetes.},
  author={Tongzhi Wu and Xiang Zhang and Laurence G. Trahair and Michelle J. Bound and Tanya J. Little and Carolyn F Deacon and Michael Horowitz and Karen L Jones and Christopher K Rayner},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2016},
  volume={101 12},
  pages={4769-4778}
}
CONTEXT The rate of gastric emptying is an important determinant of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) secretion and may influence the magnitude of glucose lowering by dipeptidyl peptidase-4 (DPP-4) inhibitors. OBJECTIVE To evaluate the effects of the DPP-4 inhibitor, vildagliptin (VILD), during intraduodenal (ID) glucose infusion at 2 different rates within the physiological range of gastric emptying, in type 2 diabetes. PARTICIPANTS AND… CONTINUE READING
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