Small Intestinal Bacterial Overgrowth in Gastroparesis: Are There Any Predictors?

@article{Reddymasu2010SmallIB,
  title={Small Intestinal Bacterial Overgrowth in Gastroparesis: Are There Any Predictors?},
  author={Savio Charan Reddymasu and Richard W. McCallum},
  journal={Journal of Clinical Gastroenterology},
  year={2010},
  volume={44},
  pages={e8-e13},
  url={https://api.semanticscholar.org/CorpusID:12058906}
}
SIBO is very common in gastroparetics with predominance of abdominal pain and bloating, especially those with a longer duration of gastroparesis, and awareness of SIBO will facilitate separation of the 2 entities and allow appropriate therapies to be instituted.
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48 Citations
Highly Influential Citations
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Background Citations
10
Methods Citations
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48 Citations

Small Intestinal Bacterial Overgrowth in Gastroparesis

Positive H2@90min testing by LBT was associated with increased symptoms of bloating and excessive fullness during and after meals, and no significant difference in symptom severity was seen between positive and negative DPHBT gastroparesis patients.

Prevalence of small intestinal bacterial overgrowth in patients with gastroparesis: a systematic review and meta-analysis

A systematic review and meta-analysis to identify the prevalence of small intestinal bacterial overgrowth (SIBO) in patients with gastroparesis found it to be present in almost half of the patients with gastroesophageal reflux disease.

Predictors of Small Intestinal Bacterial Overgrowth in Symptomatic Patients Referred for Breath Testing

The prevalence of SIBO is high in symptomatic patients who underwent breath testing and treatment ofSIBO with antibiotics needs to be further investigated to better determine its efficacy on gastrointestinal symptoms.

SIBO in Gastroparesis: Sci-fi or Science Fact?

Breath testing is a useful indirect measure of small intestinal bacterial overgrowth (SIBO) because of its simplicity, low cost, and lack of invasion, but results can be significantly affected by gut motility.

Delayed Gastric Emptying Is Not Associated with a Microbiological Diagnosis of Small Intestinal Bacterial Overgrowth

There was no significant association between a microbiological diagnosis of SIBO and delayed gastric emptying by scintigraphy, and gastroparesis symptoms did not differ significantly between patients with and without SIBO.

Small Intestinal Bacterial Overgrowth

In conclusion, the accuracy of all current tests remains limited due to the lack of reliability of culture methods and the Lack of a standard definition of the normal quantity gut flora in the small bowel.

Small intestinal bacterial overgrowth

There is abundant evidence suggesting the relationship between SIBO and irritable bowel syndrome; however, it is not clear which disease is a primary factor to the other.

Gastroparesis: pathogenesis, diagnosis and management

    W. Hasler
    Medicine
    Nature Reviews Gastroenterology &Hepatology
  • 2011
Histologic examination of gastric tissues from patients with severe gastroparesis reveals heterogeneous and inconsistent defects in the morphology of enteric neurons, smooth muscle and interstitial cells of Cajal, and increased levels of inflammatory cells.

Management of gastroparesis‐associated malnutrition

A systematic approach including initial nutritional screening, diet recommendations, medical therapy, nutritional re‐evaluation and enteral and parental nutrition should be considered in complex GP patients.

Bloating in Gastroparesis: Severity, Impact, and Associated Factors

Findings provide insight into this underappreciated symptom of gastroparesis and suggest antiemetics, probiotics, and antidepressants with significant norepinephrine reuptake inhibitor activity may affect reports of bloating.

44 References

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The results show that bacterial overgrowth may contribute to the delay of intestinal transit as confirmed by its significant improvement after eradication therapy.

Small intestinal bacterial overgrowth in patients with irritable bowel syndrome

The data do not support an important role for SIBO according to commonly used clinical definitions, in irritable bowel syndrome, however, mildly increased counts of small-bowel bacteria seem to be more common in IBS, and needs further investigation.

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Lower Frequency of MMC Is Found in IBS Subjects with Abnormal Lactulose Breath Test, Suggesting Bacterial Overgrowth

In conclusion, phase III is reduced in subjects with IBS and SIBO, and eradication of bacterial overgrowth seems to result in some normalization of motility.

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Contaminating flora isolated in S IBOS include commonly identified oropharyngeal and colonic flora, but these occur in SIBOS at different levels from those usually found in their original location.