Small Intestinal Bacterial Overgrowth Is Associated with Non-Alcoholic Fatty Liver Disease.

@article{Fialho2016SmallIB,
  title={Small Intestinal Bacterial Overgrowth Is Associated with Non-Alcoholic Fatty Liver Disease.},
  author={Andr{\'e}a BC Fialho and Andr{\'e}a BC Fialho and Prashanthi N. Thota and Arthur J. McCullough and Bo Shen},
  journal={Journal of gastrointestinal and liver diseases : JGLD},
  year={2016},
  volume={25 2},
  pages={
          159-65
        }
}
  • A. Fialho, A. Fialho, +2 authors B. Shen
  • Published 1 June 2016
  • Medicine, Biology
  • Journal of gastrointestinal and liver diseases : JGLD
BACKGROUND Changes in gut bacteria play a role in type 2 diabetes mellitus (DM) and hepatic steatosis. There is a lack of studies evaluating the frequency and risk factors for non-alcoholic fatty liver disease (NAFLD) in patients tested for small intestinal bacterial overgrowth (SIBO). AIM To evaluate the frequency of NAFLD and associated risk factors in patients tested for SIBO. METHODS In this case-control study, 372 eligible patients submitted to glucose hydrogen/methane breath test for… 
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40 Citations
Background Citations
4
Results Citations
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40 Citations

Citation Type

Citation Type

Association of small intestinal bacterial overgrowth and non-alcoholic fatty liver disease in children
TLDR
It has been found that non-alcoholic fatty liver disease is a risk factor for SIBO development and SIBO was associated with low-grade inflammation and adverse metabolic profile.
PERIPHERAL BLOOD ENDOTOXIN LEVELS ARE NOT ASSOCIATED WITH SMALL INTESTINAL BACTERIAL OVERGROWTH IN NONALCOHOLIC FATTY LIVER DISEASE WITHOUT CIRRHOSIS.
TLDR
Serum endotoxin levels did not differ between patients with and without SIBO, nor did these levels change after antibacterial therapy, virtually ruling out the possibility that elevated endotoxinemia in non-cirrhotic patients with NAFLD is associated with SIBO.
The relationship between non-alcoholic fatty liver disease and small intestinal bacterial overgrowth among overweight and obese children and adolescents
TLDR
Obese children with SIBO have an increased risk for developing nonalcoholic fatty liver disease and the relationship between intestinal dysbiosis and diet can influence the gut-liver axis, according to this study.
Association of small intestinal bacterial overgrowth with nonalcoholic fatty liver disease in children: A meta-analysis
It has been suggested that small intestinal bacterial overgrowth (SIBO) could cause nonalcoholic fatty liver disease (NAFLD), but this association was not examined in children by meta-analysis. This…
Small intestinal bacterial overgrowth and nonalcoholic fatty liver disease: a systematic review and meta-analysis
TLDR
A significant association between NAFLD and SIBO was observed in this meta-analysis and funnel plot is relatively symmetric and is not suggestive of the presence of publication bias.
Low-grade small intestinal bacterial overgrowth is common in patients with non-alcoholic steatohepatitis on quantitative jejunal aspirate culture
TLDR
Low-grade bacterial overgrowth, particularly with Gram negative bacteria, was commoner in NASH than controls and there was no correlation between bacterial colony count and bacterial type and anthropometric and biochemical parameters.
NAFLD, Helicobacter species and the intestinal microbiome.
Characteristics of intestinal bacteria with fatty liver diseases and cirrhosis.
Association between small intestinal bacterial overgrowth and beta-cell function of type 2 diabetes
TLDR
Multiple linear regression analysis showed that body mass index, glucose at 0 minutes, and SIBO were independently associated with the early-phase and total-phase insulin secretion and may be involved in lower levels of insulin release and worse glycemic control.
A review of non‐alcoholic fatty liver disease in non‐obese and lean individuals
TLDR
There is not enough evidence on the treatment of NAFLD in non‐obese patients, the standard approach is to advise altering one's lifestyle in order to diminish visceral adiposity, so dietary modification, weight loss, and increased physical activity are highly recommended.
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References

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