Small Interfering RNA Profiling Reveals Key Role of Clathrin-Mediated Endocytosis and Early Endosome Formation for Infection by Respiratory Syncytial Virus

@article{Kolokoltsov2007SmallIR,
  title={Small Interfering RNA Profiling Reveals Key Role of Clathrin-Mediated Endocytosis and Early Endosome Formation for Infection by Respiratory Syncytial Virus},
  author={A. Kolokoltsov and Drew C Deniger and E. Fleming and N. Roberts and J. Karpilow and R. Davey},
  journal={Journal of Virology},
  year={2007},
  volume={81},
  pages={7786 - 7800}
}
ABSTRACT Respiratory syncytial virus (RSV) is a common cause of respiratory tract infections in infants and the elderly. Like many other pH-independent enveloped viruses, RSV is thought to enter at the cell surface, independently of common endocytic pathways. We have used a targeted small interfering RNA (siRNA) library to identify key cellular genes involved in cytoskeletal dynamics and endosome trafficking that are important for RSV infection. Surprisingly, RSV infection was potently… Expand
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