Small Interference RNA Targeting TLR4 Gene Effectively Attenuates Pulmonary Inflammation in a Rat Model

@inproceedings{Wu2012SmallIR,
  title={Small Interference RNA Targeting TLR4 Gene Effectively Attenuates Pulmonary Inflammation in a Rat Model},
  author={Feixiang Wu and Yantao Liu and Xin Lv and Xuerong Miao and Yuming Sun and Weifeng Yu},
  booktitle={Journal of biomedicine & biotechnology},
  year={2012}
}
OBJECTIVE The present study was to investigate the feasibility of adenovirus-mediated small interference RNA (siRNA) targeting Toll-like receptor 4 (TLR4) gene in ameliorating lipopolysaccharide- (LPS-) induced acute lung injury (ALI). METHODS In vitro, alveolar macrophages (AMs) were treated with Ad-siTLR4 and Ad-EFGP, respectively, for 12 h, 24 h, and 48 h, and then with LPS (100 ng/mL) for 2 h, and the function and expression of TLR4 were evaluated. In vivo, rats received intratracheal… CONTINUE READING
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