Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms

@inproceedings{CitalnMadrid2013SmallGO,
  title={Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms},
  author={Al{\'i} Francisco Cital{\'a}n-Madrid and Alexander Garc{\'i}a-Ponce and Hilda Vargas-Robles and Abigail Betanzos and Michael Schnoor},
  booktitle={Tissue barriers},
  year={2013}
}
The intestinal epithelium forms a stable barrier protecting underlying tissues from pathogens in the gut lumen. This is achieved by specialized integral membrane structures such as tight and adherens junctions that connect neighboring cells and provide stabilizing links to the cytoskeleton. Junctions are constantly remodeled to respond to extracellular stimuli. Assembly and disassembly of junctions is regulated by interplay of actin remodeling, endocytotic recycling of junctional proteins, and… CONTINUE READING

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