Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation

@inproceedings{Egami2014SmallGA,
  title={Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation},
  author={Youhei Egami and Tomohiko Taguchi and Masashi Maekawa and Hiroyuki Arai and Nobukazu Araki},
  booktitle={Front. Physiol.},
  year={2014}
}
Macropinosome formation requires the sequential activation of numerous signaling pathways that coordinate the actin-driven formation of plasma membrane protrusions (ruffles) and circular ruffles (macropinocytic cups), followed by the closure of these macropinocytic cups into macropinosomes. In the process of macropinosome formation, localized productions of phosphoinositides such as PI(4,5)P2 and PI(3,4,5)P3 spatiotemporally orchestrate actin polymerization and rearrangement through recruiting… CONTINUE READING
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