Small GTP-binding proteins of the Rho- and Ras-subfamilies are not involved in the actin rearrangements induced by attaching and effacing Escherichia coli.

@article{Ebel1998SmallGP,
  title={Small GTP-binding proteins of the Rho- and Ras-subfamilies are not involved in the actin rearrangements induced by attaching and effacing Escherichia coli.},
  author={Frank Ebel and Christoph von Eichel-Streiber and Manfred Rohde and Tirtha Chakraborty},
  journal={FEMS microbiology letters},
  year={1998},
  volume={163 2},
  pages={
          107-12
        }
}
Attaching and effacing Escherichia coli (AEEC) are extracellular pathogens that induce the formation of actin-rich structures at their sites of attachment to eukaryotic host cells. We analysed whether small GTP-binding proteins of the Rho- and Ras-subfamilies, which control the cellular actin system, are essential for these bacterial-induced microfilament reorganizations. For this purpose we specifically inactivated them using the Clostridium difficile toxins TcdB-10463 and TcdB-1470. Such… CONTINUE READING

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