Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes.

@article{Kanzaki2002SmallGP,
  title={Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes.},
  author={Makoto Kanzaki and Robert T. Watson and June Chunqiu Hou and Mark Stamnes and Alan R. Saltiel and Jeffrey E. Pessin},
  journal={Molecular biology of the cell},
  year={2002},
  volume={13 7},
  pages={2334-46}
}
TC10 is a member of the Rho family of small GTP-binding proteins that has previously been implicated in the regulation of insulin-stimulated GLUT4 translocation in adipocytes. In a manner similar to Cdc42-stimulated actin-based motility, we have observed that constitutively active TC10 (TC10/Q75L) can induce actin comet tails in Xenopus oocyte extracts in vitro and extensive actin polymerization in the perinuclear region when expressed in 3T3L1 adipocytes. In contrast, expression of TC10/Q75L… CONTINUE READING

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