Small‐molecule elicitation of microbial secondary metabolites

  title={Small‐molecule elicitation of microbial secondary metabolites},
  author={Robin K. Pettit},
  booktitle={Microbial biotechnology},
Microbial natural products continue to be an unparalleled resource for pharmaceutical lead discovery, but the rediscovery rate is high. Bacterial and fungal sequencing studies indicate that the biosynthetic potential of many strains is much greater than that observed by fermentation. Prodding the expression of such silent (cryptic) pathways will allow us to maximize the chemical diversity available from microorganisms. Cryptic metabolic pathways can be accessed in the laboratory using molecular… CONTINUE READING

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