Smads bind directly to the Jun family of AP-1 transcription factors.

  title={Smads bind directly to the Jun family of AP-1 transcription factors.},
  author={Nicole T. Liberati and Michael B. Datto and Joshua P. Frederick and Xinchun Shen and Carolyn Wong and ELISSA M. ROUGIER-CHAPMAN and X F Wang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 9},
Smad3 and Smad4 are sequence-specific DNA-binding factors that bind to their consensus DNA-binding sites in response to transforming growth factor beta (TGFbeta) and activate transcription. Recent evidence implicates Smad3 and Smad4 in the transcriptional activation of consensus AP-1 DNA-binding sites that do not interact with Smads directly. Here, we report that Smad3 and Smad4 can physically interact with AP-1 family members. In vitro binding studies demonstrate that both Smad3 and Smad4 bind… CONTINUE READING

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