Smads as therapeutic targets for chronic kidney disease

  • Hui Lan
  • Published 2012 in Kidney research and clinical practice


Renal fibrosis is a hallmark of chronic kidney disease (CKD). It is generally thought that transforming growth factor-β1 (TGF-β1) is a key mediator of fibrosis and mediates renal scarring positively by Smad2 and Smad3, but negatively by Smad7. Our recent studies found that in CKD, TGF-β1 is not a sole molecule to activate Smads. Many mediators such as… (More)
DOI: 10.1016/j.krcp.2011.12.001

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