Smad9 is a new type of transcriptional regulator in bone morphogenetic protein signaling

  title={Smad9 is a new type of transcriptional regulator in bone morphogenetic protein signaling},
  author={Sho Tsukamoto and Takato Mizuta and Mai Fujimoto and Satoshi Ohte and Kayo Osawa and Arei Miyamoto and Katsumi Yoneyama and Eiko Murata and Aiko Machiya and Eijiro Jimi and Shoichiro Kokabu and Takenobu Katagiri},
  booktitle={Scientific reports},
Smad1, Smad5 and Smad9 (also known as Smad8) are activated by phosphorylation by bone morphogenetic protein (BMP)-bound type I receptor kinases. We examined the role of Smad1, Smad5, and Smad9 by creating constitutively active forms (Smad(DVD)). Transcriptional activity of Smad9(DVD) was lower than that of Smad1(DVD) or Smad5(DVD), even though all three Smad(DVD)s associated with Smad4 and bound to the target DNA. The linker region of Smad9 was sufficient to reduce transcriptional activity… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 23 extracted citations


Publications referenced by this paper.
Showing 1-10 of 52 references

Identification of a novel bone morphogenetic protein (BMP)inducible transcript, BMP-inducible transcript-1, by utilizing the conserved BMP-responsive elements in the Id genes

M Shin
J. Bone. Miner. Metab. 31, • 2013

a critical role of the Smad signaling pathway

T. Katagiri, Tsukamoto, S. The unique activity of bone morphogenetic proteins bone
Biol. Chem. 394, 703–714 • 2013

roles of other TGFb superfamily members in cancer

L. M. Wakefield, Hill, C. S. Beyond TGFb
Nat. Rev. Cancer. 13, 328–341 • 2013

Identification and functional analysis of Zranb 2 as a novel Smadbinding protein that suppresses BMP signaling

S. Ohte
J . Cell . Biochem . • 2012

Similar Papers

Loading similar papers…