Smad7-induced beta-catenin degradation alters epidermal appendage development.

@article{Han2006Smad7inducedBD,
  title={Smad7-induced beta-catenin degradation alters epidermal appendage development.},
  author={Gangwen Han and Allen Guanqun Li and Yao-Yun Liang and Philip Owens and Wei He and Shilong Lu and Yasuhiro Yoshimatsu and Donna Wang and Peter Ten Dijke and Xia Lin and Xiao-Jing Wang},
  journal={Developmental cell},
  year={2006},
  volume={11 3},
  pages={301-12}
}
To assess whether Smad signaling affects skin development, we generated transgenic mice in which a Smad antagonist, Smad7, was induced in keratinocytes, including epidermal stem cells. Smad7 transgene induction perturbed hair follicle morphogenesis and differentiation, but accelerated sebaceous gland morphogenesis. Further analysis revealed that independent of its role in anti-Smad signaling, Smad7 bound beta-catenin and induced beta-catenin degradation by recruiting an E3 ligase, Smurf2, to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 57 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Transient activation of b-catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice

D. Van Mater, F. T. Kolligs, A. A. Dlugosz, E. R. Fearon
Genes Dev. 17, 1219–1224. • 2003
View 5 Excerpts
Highly Influenced

Smad transcription factors.

Genes & development • 2005
View 5 Excerpts
Highly Influenced

Unexpected Hedgehog-Wnt interactions in epithelial differentiation.

Trends in molecular medicine • 2004
View 5 Excerpts
Highly Influenced

Hedgehog signaling regulates sebaceous gland development.

The American journal of pathology • 2003
View 5 Excerpts
Highly Influenced

Hair follicle stem cells.

Seminars in cell & developmental biology • 2007
View 2 Excerpts

Similar Papers

Loading similar papers…