Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression.

@article{Fantini2009Smad7CR,
  title={Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression.},
  author={Massimo Claudio Fantini and Angelamaria Rizzo and Daniele Fina and Roberta Caruso and Massimiliano Sarra and Carmine Stolfi and Christoph Becker and Thomas Macdonald and Francesco Pallone and Markus F Neurath and Giovanni Monteleone},
  journal={Gastroenterology},
  year={2009},
  volume={136 4},
  pages={1308-16, e1-3}
}
BACKGROUND & AIMS Foxp3-expressing regulatory T cells (Tregs) play a key role in the maintenance of the gut immune homeostasis, and an intact transforming growth factor (TGF)-beta signaling is required for their function. In inflammatory bowel disease (IBD), the TGF-beta signaling is impaired because of high expression of the inhibitory molecule Smad7. Although no intrinsic defects in Tregs function have been shown in IBD, it is still unknown whether colitogenic T cells are susceptible to Treg… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 75 extracted citations

References

Publications referenced by this paper.

Inhibition of Smad 7 with a specific antisense oligonucleotide facilitates TGF 1mediated suppression of colitis

M Boirivant, F Pallone, C DiGiacinto
Gastroenterology • 2006

Similar Papers

Loading similar papers…