Smad7 Promotes Healing of Radiotherapy-Induced Oral Mucositis without Compromising Oral Cancer Therapy in a Xenograft Mouse Model

@article{Luo2018Smad7PH,
  title={Smad7 Promotes Healing of Radiotherapy-Induced Oral Mucositis without Compromising Oral Cancer Therapy in a Xenograft Mouse Model},
  author={Jingjing Luo and L. Bian and Melanie A. Blevins and Dongyan D. Wang and Chao Liang and Danfeng Du and Fanglong Wu and Barry C. Holwerda and Rui Zhao and D. Raben and Hongmei Zhou and C. Young and Xiao-Jing Wang},
  journal={Clinical Cancer Research},
  year={2018},
  volume={25},
  pages={808 - 818}
}
Purpose: We previously reported preventive and therapeutic effects of Smad7, a multifunctional protein, on radiotherapy (RT)-induced mucositis in mice without promoting human oral cancer cell survival or migration in vitro. The current study aims to determine whether a Smad7-based biologic can treat existing oral mucositis during radiotherapy for oral cancer and whether this treatment compromises RT-induced cancer cell killing in neighboring oral cancer. Experimental Design: We transplanted… Expand
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