Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription.

@article{Lin2003Smad6RT,
  title={Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription.},
  author={Xia Lin and Yao-Yun Liang and Baohua Sun and Min Liang and Yujiang Geno Shi and Francis Charles Brunicardi and Yang Shi and Xin-hua Feng},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 24},
  pages={9081-93}
}
Smad6 and Smad7 are inhibitory Smads induced by transforming growth factor beta-Smad signal transduction pathways in a negative-feedback mechanism. Previously it has been thought that inhibitory Smads bind to the type I receptor and block the phosphorylation of receptor-activated Smads, thereby inhibiting the initiation of Smad signaling. Conversely, few studies have suggested the possible nuclear functions of inhibitory Smads. Here, we present compelling evidence demonstrating that Smad6… CONTINUE READING
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