Smad4 suppresses the tumorigenesis and aggressiveness of neuroblastoma through repressing the expression of heparanase

Abstract

Heparanase (HPSE) is the only endo-β-D-glucuronidase that is correlated with the progression of neuroblastoma (NB), the most common extracranial malignancy in childhood. However, the mechanisms underlying HPSE expression in NB still remain largely unknown. Herein, through analyzing cis-regulatory elements and mining public microarray datasets, we identified… (More)
DOI: 10.1038/srep32628

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@inproceedings{Qu2016Smad4ST, title={Smad4 suppresses the tumorigenesis and aggressiveness of neuroblastoma through repressing the expression of heparanase}, author={Hongxia Qu and Li-duan Zheng and Wanju Jiao and Hong Mei and Dan Li and Huajie Song and Erhu Fang and Xiaojing Wang and Shiwang Li and Kai Huang and Qiang-song Tong}, booktitle={Scientific reports}, year={2016} }