Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer.

@article{Bardeesy2006Smad4ID,
  title={Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer.},
  author={Nabeel Bardeesy and Kuang-hung Cheng and Justin H. Berger and Gerald C. Chu and Jessica C. Pahler and Peter Olson and Aram F. Hezel and James F Horner and Gregory Yves Lauwers and Douglas Hanahan and Ronald A. Depinho},
  journal={Genes & development},
  year={2006},
  volume={20 22},
  pages={3130-46}
}
SMAD4 is inactivated in the majority of pancreatic ductal adenocarcinomas (PDAC) with concurrent mutational inactivation of the INK4A/ARF tumor suppressor locus and activation of the KRAS oncogene. Here, using genetically engineered mice, we determined the impact of SMAD4 deficiency on the development of the pancreas and on the initiation and/or progression of PDAC-alone or in combination with PDAC--relevant mutations. Selective SMAD4 deletion in the pancreatic epithelium had no discernable… CONTINUE READING
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