Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells

@article{Mueller2002Smad4IT,
  title={Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells},
  author={Nicole Mueller and Anke C Reinacher-Schick and Stephan Baldus and Jolanda van Hengel and Geert Berx and Anke Baar and Frans van Roy and Wolff Schmiegel and Irmgard Schwarte-Waldhoff},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={6049-6058}
}
Smad4 is an intracellular transmitter of TGF-β signals and its tumor suppressor function is presumed to reside in its capacity to mediate TGF-β-induced growth inhibition. However, there is accumulating evidence that this hypothesis may be too simple. The roles of TGF-β in carcinogenesis are complex and also comprise tumor promoting functions particularly in late stage carcinogenesis. Importantly, functional inactivation of Smad4 in colon carcinomas frequently occurs at late stages when tumors… CONTINUE READING