Smad4-Shh-Nfic Signaling Cascade–Mediated Epithelial-Mesenchymal Interaction Is Crucial in Regulating Tooth Root Development

@inproceedings{Huang2010Smad4ShhNficSC,
  title={Smad4-Shh-Nfic Signaling Cascade–Mediated Epithelial-Mesenchymal Interaction Is Crucial in Regulating Tooth Root Development},
  author={Xiaofeng Huang and Xun Xu and Pablo O Bringas and Yee Ping Hung and Yang Chai},
  booktitle={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2010}
}
Transforming growth factor beta (TGF-beta)/bone morphogenetic protein (BMP) signaling is crucial for regulating epithelial-mesenchymal interaction during organogenesis, and the canonical Smad pathway-mediated TGF-beta/BMP signaling plays important roles during development and disease. During tooth development, dental epithelial cells, known as Hertwig's epithelial root sheath (HERS), participate in root formation following crown development. However, the functional significance of HERS in… CONTINUE READING
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