Smad4-Irf6 genetic interaction and TGFβ-mediated IRF6 signaling cascade are crucial for palatal fusion in mice.

Abstract

Cleft palate is one of the most common human birth defects and is associated with multiple genetic and environmental risk factors. Although mutations in the genes encoding transforming growth factor beta (TGFβ) signaling molecules and interferon regulatory factor 6 (Irf6) have been identified as genetic risk factors for cleft palate, little is known about… (More)
DOI: 10.1242/dev.089615

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Cite this paper

@article{Iwata2013Smad4Irf6GI, title={Smad4-Irf6 genetic interaction and TGFβ-mediated IRF6 signaling cascade are crucial for palatal fusion in mice.}, author={Jun-ichi Iwata and Akiko Suzuki and Richard C. Pelikan and T Ho and Pedro A. Sanchez-Lara and Mark M. Urata and M. Dixon and Yang Chai}, journal={Development}, year={2013}, volume={140 6}, pages={1220-30} }