Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis.

  title={Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis.},
  author={Irmgard Schwarte-Waldhoff and Olga V. Volpert and No{\"e}l P. Bouck and Bence Sipos and Stephan A. Hahn and Susanne Klein-Scory and Jutta Luettges and Guenter Kloeppel and Ullrich Graeven and Christina Eilert-Micus and Annette Hintelmann and Wolff Schmiegel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 17},
Smad4/DPC4 (deleted in pancreatic carcinoma, locus 4) is a tumor suppressor gene lost at high frequency in cancers of the pancreas and other gastrointestinal organs. Smad4 encodes a key intracellular messenger in the transforming growth factor beta (TGF-beta) signaling cascade. TGF-beta is a potent inhibitor of the growth of epithelial cells; thus, it has… CONTINUE READING