Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells.

@article{Chen2002Smad4DPC4dependentRO,
  title={Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells.},
  author={Wen-Bin Chen and Wolfgang Lenschow and Karen Tiede and Jens Walter Fischer and Holger Kalthoff and Hendrik Ungefroren},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 39},
  pages={36118-28}
}
Overexpression of the small leucine-rich proteoglycan biglycan (BGN) in fibrosis and desmoplasia results from enhanced activity of transforming growth factor-beta (TGF-beta). In pancreatic adenocarcinoma, the tumor cells themselves may contribute to BGN synthesis in vivo, since 8 of 18 different pancreatic carcinoma cell lines constitutively expressed BGN mRNA, as shown by reverse transcription-PCR analysis. In PANC-1 cells, TGF-beta1 dramatically stimulated BGN mRNA accumulation through a BGN… CONTINUE READING

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