Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury.

@article{Saika2004Smad3SI,
  title={Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury.},
  author={Shizuya Saika and Satoko Kono-Saika and Yoshitaka Ohnishi and Misako Sato and Yasuteru Muragaki and Akira Ooshima and Kathleen C. Flanders and J Leslie Yoo and Mario B Anzano and Chia-Yang Liu and Winston W. Y. Kao and Anita B. Roberts},
  journal={The American journal of pathology},
  year={2004},
  volume={164 2},
  pages={651-63}
}
Lens epithelial cells undergo epithelial-mesenchymal transition (EMT) after injury as in cataract extraction, leading to fibrosis of the lens capsule. Fibrosis of the anterior capsule can be modeled in the mouse by capsular injury in the lens, which results in EMT of the lens epithelium and subsequent deposition of extracellular matrix without contamination of other cell types from outside the lens. We have previously shown that signaling via Smad3, a key signal-transducing element downstream… CONTINUE READING
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