Smad3 inhibits transforming growth factor-beta and activin signaling by competing with Smad4 for FAST-2 binding.

@article{Nagarajan1999Smad3IT,
  title={Smad3 inhibits transforming growth factor-beta and activin signaling by competing with Smad4 for FAST-2 binding.},
  author={Raman P. Nagarajan and Jun Liu and Yihong Chen},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 44},
  pages={31229-35}
}
Transcriptional regulation by transforming growth factor-beta and activin is mediated by interaction of Smad2 and Smad3 with specific transcription factors and/or DNA elements. However, Smad3 behaves differently from Smad2 in regulating transcription by a winged-helix transcription factor, FAST-2, on an activin-responsive element (ARE) in the Xenopus Mix.2… CONTINUE READING