Smad3 deficiency inhibits v-ras-induced transformation by suppression of JNK MAPK signaling and increased farnesyl transferase inhibition

Abstract

The ability of transforming growth factor-β (TGF-β) to modulate various effects on distinct cell lineages has been a central feature of its multi-faceted nature. The purpose of this study was to access the effects of deletion of a key TGF-β signal transducer, Smad3, on MAPK activation and v-RasHa-transformation of primary mouse embryonic fibroblasts (MEFs… (More)
DOI: 10.1038/sj.onc.1210889

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