Smad3 activates the Sox9-dependent transcription on chromatin.

  title={Smad3 activates the Sox9-dependent transcription on chromatin.},
  author={Takayuki Furumatsu and Toshifumi Ozaki and Hiroshi Asahara},
  journal={The international journal of biochemistry & cell biology},
  volume={41 5},
Transforming growth factor (TGF)-beta has an essential role for the Sry-type high-mobility-group box (Sox)-regulated chondrogenesis. Chondrogenic differentiation is also controlled by chromatin-mediated transcription. We have previously reported that TGF-beta-regulated Smad3 induces chondrogenesis through the activation of Sox9-dependent transcription. However, the cross-talk between TGF-beta signal and Sox9 on chromatin-mediated transcription has not been elucidated. In the present study, we… CONTINUE READING

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