Smad2 and Smad4 gene mutations in hepatocellular carcinoma

@article{Yakicier1999Smad2AS,
  title={Smad2 and Smad4 gene mutations in hepatocellular carcinoma},
  author={Mustafa Cengiz Yakicier and Meliha Burcu Irmak and Alfredo Romano and Michael Kew and Mehmet Fatih Ozturk},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={4879-4883}
}
TGF-β is a negative regulator of liver growth. Smad family of genes, as mediators of TGF-β pathway, are candidate tumor suppressor genes in hepatocellular carcinoma (HCC). We studied 35 HCC and non-tumour liver tissues for possible mutations in Smad2 and Smad4 genes. Three tumours displayed somatic mutations; two in Smad4 (Asp332Gly and Cys401Arg) and one in Smad2 (Gln407Arg) genes. All three mutations were A:T → G:C transitions suspected to result from oxidative stress as observed in… CONTINUE READING

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