Smad2-Dependent Downregulation of miR-30 Is Required for TGF-β-Induced Apoptosis in Podocytes

@inproceedings{Shi2013Smad2DependentDO,
  title={Smad2-Dependent Downregulation of miR-30 Is Required for TGF-β-Induced Apoptosis in Podocytes},
  author={Shaolin Shi and Liping Yu and Taoran Zhang and Haiying Qi and Santiago Xavier and Wenjun Ju and Erwin Bottinger},
  booktitle={PloS one},
  year={2013}
}
Transforming growth factors beta (TGF-β) are multi-functional cytokines capable of inducing apoptosis in epithelial cells, including glomerular podocytes. We and others have previously shown that podocyte-selective genetic deletion of the microRNA (miR)-processing enzyme, Dicer, caused glomerulosclerosis that was associated with podocyte apoptosis, and the miR-30 family was implicated in the process. Here, we report that apoptosis-associated genes were highly enriched among the predicted… CONTINUE READING

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