Smad1 protects cardiomyocytes from ischemia-reperfusion injury.

  title={Smad1 protects cardiomyocytes from ischemia-reperfusion injury.},
  author={Mitsuru Masaki and Masahiro Izumi and Yuichi Oshima and Yoshikazu Nakaoka and Tadashi Kuroda and Ryusuke Kimura and Shoko Sugiyama and Kazuo Terai and Masafumi Kitakaze and Keiko Yamauchi-Takihara and Ichiro Kawase and Hisao Hirota},
  volume={111 21},
BACKGROUND We previously reported that bone morphogenetic protein 2 (BMP2) protected against apoptosis of serum-deprived cardiomyocytes via induction of Bcl-xL through the Smad1 pathway. To investigate whether Smad1 signaling promotes cell survival in the adult heart, we subjected transgenic mice with cardiac-specific overexpression of smad1 gene (Smad1TG) to ischemia-reperfusion (I/R) injury. METHODS AND RESULTS The effects of BMP2 or adenovirus-mediated transfection of smad1 on… CONTINUE READING


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FAK regulates cardiomyocyte survival following ischemia/reperfusion.

Journal of molecular and cellular cardiology • 2009
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