Smad proteins regulate transcriptional induction of the SM22alpha gene by TGF-beta.

@article{Chen2003SmadPR,
  title={Smad proteins regulate transcriptional induction of the SM22alpha gene by TGF-beta.},
  author={Shiyou Chen and Magdalena A. Kulik and Robert J. Lechleider},
  journal={Nucleic acids research},
  year={2003},
  volume={31 4},
  pages={1302-10}
}
Smad proteins transduce signals from transforming growth factor-beta (TGF-beta) receptors and regulate transcription of target genes. TGF-beta is implicated in the regulation of the smooth muscle cell specific gene SM22alpha, but little is known about how Smads are involved in SM22alpha gene transcription. In this report, we demonstrate that TGF-beta activation of the SM22alpha promoter is Smad dependent in C3H10T1/2 cells, BALB 3T3 cells and neural crest Monc-1 cells. We find that the promoter… CONTINUE READING

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