Smad linker region phosphorylation in the regulation of extracellular matrix synthesis

@article{Burch2010SmadLR,
  title={Smad linker region phosphorylation in the regulation of extracellular matrix synthesis},
  author={Micah L. Burch and Wenhua Zheng and Peter J Little},
  journal={Cellular and Molecular Life Sciences},
  year={2010},
  volume={68},
  pages={97-107}
}
The canonical TGF-β signalling pathway involves Smad transcription factors through direct serine phosphorylation of the carboxy termini, nuclear translocation and regulation of transcription by receptor-regulated (R)-Smad complexes. Smads can also be phosphorylated in the linker region most prominently by the action of mitogen-activated protein (MAP) kinases, which in turn have been activated by TGF-β or a multitude of other growth factors and hormones. Linker region phosphorylation can prevent… CONTINUE READING

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