Smad interacting protein 1 as a regulator of skin fibrosis in pathological scars.

@article{Zhang2011SmadIP,
  title={Smad interacting protein 1 as a regulator of skin fibrosis in pathological scars.},
  author={Zhan-feng Zhang and Yan-gang Zhang and Dahai Hu and Ji-hong Shi and Jia-qi Liu and Zhou-ting Zhao and Hongtao Wang and Xiao-zhi Bai and Wei-xia Cai and Hua-yu Zhu and Chao-wu Tang},
  journal={Burns : journal of the International Society for Burn Injuries},
  year={2011},
  volume={37 4},
  pages={665-72}
}
Keloids and hypertrophic scars are significant symptomatic clinical problems characterized by the excessive and abnormal deposition of collagen-based extracellular matrix (ECM) components. However, the molecular basis of keloid and hypertrophic scar formation has not been fully elucidated. Here, we demonstrated that down-regulation of the transcription factor Smad interacting protein 1 (SIP1) could be relevant to keloid and hypertrophic scar formation. The results of the present study show that… CONTINUE READING