Smad-dependent and Smad-independent pathways in TGF-β family signalling

  title={Smad-dependent and Smad-independent pathways in TGF-β family signalling},
  author={R. Derynck and Ying E. Zhang},
  • R. Derynck, Ying E. Zhang
  • Published 2003
  • Biology
  • Nature
  • Transforming growth factor-β (TGF-β) proteins regulate cell function, and have key roles in development and carcinogenesis. The intracellular effectors of TGF-β signalling, the Smad proteins, are activated by receptors and translocate into the nucleus, where they regulate transcription. Although this pathway is inherently simple, combinatorial interactions in the heteromeric receptor and Smad complexes, receptor-interacting and Smad-interacting proteins, and cooperation with sequence-specific… CONTINUE READING
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