Smac mimetics as new cancer therapeutics.

  title={Smac mimetics as new cancer therapeutics.},
  author={Derrick J Chen and S Huerta},
  journal={Anti-cancer drugs},
  volume={20 8},
The recent discovery of Smac and the elucidation of its structure and function have led to the rapid development of Smac mimetics, comprising Smac derivative and mimicking molecules, for use in cancer treatment. Smac is an endogenous proapoptotic protein that resides in the mitochondria and is released when a cell is triggered to undergo programmed cell death. One of the mechanisms by which Smac promotes apoptosis is through its ability to inhibit inhibitors of apoptosis (IAPs), by direct… CONTINUE READING


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