Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis.

@article{Laukens2011SmacMB,
  title={Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis.},
  author={Bram Laukens and Claudia Jennewein and Barbara Schenk and Nele Vanlangenakker and Alexander F Schier and Silvia Cristofanon and Kerry Zobel and Kurt D Deshayes and Domagoj Vucic and Irmela Jeremias and Mathieu M J Bertrand and Peter Vandenabeele and Simone Fulda},
  journal={Neoplasia},
  year={2011},
  volume={13 10},
  pages={971-9}
}
Searching for new strategies to bypass apoptosis resistance, we investigated the potential of the Smac mimetic BV6 in Jurkat leukemia cells deficient in key molecules of the death receptor pathway. Here, we demonstrate for the first time that Smac mimetic primes apoptosis-resistant, FADD- or caspase-8-deficient leukemia cells for TNFα-induced necroptosis in a synergistic manner. In contrast to TNFα, Smac mimetic significantly enhances CD95-induced apoptosis in wild-type but not in FADD… CONTINUE READING