Sm22.6 antigen is an inhibitor to human thrombin.

  title={Sm22.6 antigen is an inhibitor to human thrombin.},
  author={Ya-ling Lin and Shiping He},
  journal={Molecular and biochemical parasitology},
  volume={147 1},
The physiological role of Schistosomiasis mansoni 22.6 antigen (sm22.6 Ag) and its pathogenic effect on the human host has never been reported. Recombinant sm22.6 Ag is a homogenous polymer under non-denaturing/non-reducing conditions, and an inhibitor to human thrombin. Kinetic and Western blot assays show that the recombinant protein interacts with human thrombin and inhibits proteolytic activity of the protease. Tests of whole blood revealed that coagulation time was significantly delayed (3… CONTINUE READING

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