Sm proteins specify germ cell fate by facilitating oskar mRNA localization.

@article{Gonsalvez2010SmPS,
  title={Sm proteins specify germ cell fate by facilitating oskar mRNA localization.},
  author={Graydon B Gonsalvez and T. K. Rajendra and Ying Wen and Kavita Praveen and A Gregory Matera},
  journal={Development},
  year={2010},
  volume={137 14},
  pages={2341-51}
}
Sm and Sm-like proteins are RNA-binding factors found in all three domains of life. Eukaryotic Sm proteins play essential roles in pre-mRNA splicing, forming the cores of spliceosomal small nuclear ribonucleoproteins (snRNPs). Recently, Sm proteins have been implicated in the specification of germ cells. However, a mechanistic understanding of their involvement in germline specification is lacking and a germline-specific RNA target has not been identified. We demonstrate that Drosophila SmB and… CONTINUE READING

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