SlyA, a regulatory protein from Salmonella typhimurium, induces a haemolytic and pore-forming protein in Escherichia coli

@article{Ludwig1995SlyAAR,
  title={SlyA, a regulatory protein from Salmonella typhimurium, induces a haemolytic and pore-forming protein in Escherichia coli},
  author={Albrecht Ludwig and Claudia Tengel and Susanne E. Bauer and Andreas Bubert and Roland Benz and Hans-Joachim Mollenkopf and W. Goebel},
  journal={Molecular and General Genetics MGG},
  year={1995},
  volume={249},
  pages={474-486}
}
A chromosomal fragment from Salmonella typhimurium, when cloned in Escherichia coli, generates a haemolytic phenotype. This fragment carries two genes, termed slyA and slyB. The expression of slyA is sufficient for the haemolytic phenotype. The haemolytic activity of E. coli carrying multiple copies of slyA is found mainly in the cytoplasm, with some in the periplasm of cells grown to stationary phase, but overexpression of SlyB, a 15 kDa lipoprotein probably located in the outer membrane, may… CONTINUE READING