Slug is a key mediator of hypoxia induced cadherin switch in HNSCC: correlations with poor prognosis.

@article{Zhang2013SlugIA,
  title={Slug is a key mediator of hypoxia induced cadherin switch in HNSCC: correlations with poor prognosis.},
  author={Jiali Zhang and Qian Cheng and Yi Zhou and Yu Wang and Xinming Chen},
  journal={Oral oncology},
  year={2013},
  volume={49 11},
  pages={1043-50}
}
OBJECTIVES According to recent studies, the function of Slug in hypoxia induced cadherin switch differs from cancer to cancer. Whether Slug is an essential mediator of the tumor hypoxia induced cadherin switch in head and neck squamous cell carcinoma (HNSCC) and the prognostic role of Slug in HNSCC patients are not elucidated. The aim of this study is to investigate the role of the Slug in cadherin switch induced by hypoxia in HNSCC. MATERIALS AND METHODS Two HNSCC cell lines and 119 HNSCC… CONTINUE READING