Slug is a direct Notch target required for initiation of cardiac cushion cellularization

@article{Niessen2008SlugIA,
  title={Slug is a direct Notch target required for initiation of cardiac cushion cellularization},
  author={Kyle Niessen and Yangxin Fu and Linda J. Chang and Pamela A. Hoodless and Deborah E. McFadden and Aly Karsan},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={182},
  pages={315 - 325}
}
Snail family proteins are key regulators of epithelial-mesenchymal transition, but their role in endothelial-to-mesenchymal transition (EMT) is less well studied. We show that Slug, a Snail family member, is expressed by a subset of endothelial cells as well as mesenchymal cells of the atrioventricular canal and outflow tract during cardiac cushion morphogenesis. Slug deficiency results in impaired cellularization of the cardiac cushion at embryonic day (E)-9.5 but is compensated by increased… CONTINUE READING
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