Slug expression during melanoma progression.

  title={Slug expression during melanoma progression.},
  author={Stephanie Harkey Shirley and Victoria R Greene and Lyn McDivitt Duncan and Carlos A Torres Cabala and Elizabeth Ann Grimm and Donna Frances Kusewitt},
  journal={The American journal of pathology},
  volume={180 6},
Slug (Snai2), a member of the Snail family of zinc finger transcription factors, plays a role in the epithelial-to-mesenchymal transformation (EMT) that occurs during melanocyte emigration from the neural crest. A role for Slug in the EMT-like loss of cell adhesion and increased cell motility exhibited during melanoma progression has also been proposed. Our immunohistochemical studies of melanoma arrays, however, revealed that Slug expression was actually higher in nevi than in primary or… CONTINUE READING

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An overview of epithelio-mesenchymal transformation

  • ED Hay
  • Acta Anat (Basel)
  • 1995
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