Slr0077 of Synechocystis has cysteine desulfurase as well as cystine lyase activity.

@article{Kessler2004Slr0077OS,
  title={Slr0077 of Synechocystis has cysteine desulfurase as well as cystine lyase activity.},
  author={Dorothea Kessler},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={320 2},
  pages={
          571-7
        }
}
  • D. Kessler
  • Published 23 July 2004
  • Biology, Medicine
  • Biochemical and biophysical research communications
NifS-like proteins activate sulfur for a variety of biosynthetic purposes. The genome of the cyanobacterium Synechocystis contains 4 nifS-related sequences of which only the slr0077 gene seems to be essential. In this report the heterologous production of the Slr0077 protein, its purification, and catalytic properties are described. Slr0077 produces alanine as well as pyruvate from cyst(e)ine as substrate; the product ratio depends on the redox conditions. Alanine is the typical product of… 
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It is demonstrated that C-DES sequences are present in all cyanobacterial genomes and constitute a new family of sulfur-mobilizing enzymes, distinct from cysteine desulfurases, which might represent a mechanism that allows adaptation of cyanobacteria to different environmental conditions and to light-dark cycles.
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On the basis of the transcriptional profiling of all nifS‐like genes in Anabaena, it is concluded that alr2505 is the only cysteine desulfurase‐encoding gene induced by oxidative stress.
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This review gives an overview of sulfur incorporation into biomolecules in prokaryotes with a special emphasis on the properties and the enzymatic generation of persulfidic sulfur as well as its use in biosynthetic pathways.
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Understanding the roles of promiscuous vs. dedicated cysteine desulfurases and their partnership with shared-intermediates in the biosynthesis of thio-cofactors will help to map sulfur transfer events across interconnected pathways and to provide insight into the hierarchy of sulfur incorporation into biomolecules.
Current knowledge and recent advances in understanding metabolism of the model cyanobacterium Synechocystis sp. PCC 6803
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A comprehensive summary of the knowledge on cyanobacterial physiology and the pathways in Synechocystis sp.
Current knowledge and recent advances in understanding metabolism of the 1 model cyanobacterium Synechocystis sp . PCC 6803
16 Cyanobacteria are key organisms in the global ecosystem, useful models for 17 studying metabolic and physiological processes conserved in photosynthetic 18 organisms, and potential renewable…
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The objective of this project was to investigate a gene in P. falciparum with marked homology to SufS, a cysteine desulphurase of the SUF system in Escherichia coli and Arabidopsis thaliana, and make attempts to produce recombinant PfSufS for enzymological studies.
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This review focuses on the interesting and unique aspects of Fe/S cluster biogenesis in photosynthetic organisms and compares them to what is known in other organisms.
Death by Cystine: an Adverse Emergent Property from a Beneficial Series of Reactions
  • L. Reitzer
  • Medicine, Biology
    Journal of bacteriology
  • 2015
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It is shown that oxidative stress kills sulfur-restricted Escherichia coli grown with sublethal H2O2 when challenged with cystine, suggesting a cysteine-mediated vulnerability emerges during the transition from a sulfur- restricted to a sulfur -replete environment.
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