SlpE is a calcium-dependent cytotoxic metalloprotease associated with clinical isolates of Serratia marcescens.

@article{Stella2017SlpEIA,
  title={SlpE is a calcium-dependent cytotoxic metalloprotease associated with clinical isolates of Serratia marcescens.},
  author={Nicholas A. Stella and Jake D Callaghan and Liang Zhang and Kimberly M. Brothers and Regis Paul Kowalski and Jean J Huang and Patrick H Thibodeau and Robert M Q Shanks},
  journal={Research in microbiology},
  year={2017},
  volume={168 6},
  pages={
          567-574
        }
}
Serralysin-like proteases are found in a wide variety of bacteria. These metalloproteases are frequently implicated in virulence and are members of the widely conserved RTX-toxin family. We identified a serralysin-like protease in the genome of a clinical isolate of Serratia marcescens that is highly similar to the canonical serralysin protein, PrtS. This gene was named serralysin-like protease E, SlpE, and was found in the majority (67%) of tested clinical isolates, but was absent from most… CONTINUE READING