Slowly progressing form of type 1 diabetes mellitus in children: genetic analysis compared with other forms of diabetes mellitus in Japanese children.

@article{Ohtsu2005SlowlyPF,
  title={Slowly progressing form of type 1 diabetes mellitus in children: genetic analysis compared with other forms of diabetes mellitus in Japanese children.},
  author={Shigeyuki Ohtsu and Noriyuki Takubo and Mayumi Kazahari and Keiko Nomoto and Fumiyuki Yokota and Nobuyuki Kikuchi and Akemi Koike and Nobuo Matsuura},
  journal={Pediatric diabetes},
  year={2005},
  volume={6 4},
  pages={221-9}
}
AIMS Slowly progressing insulin-dependent diabetes mellitus (SPIDDM, hereafter referred to as IDDMS in this article) is a unique subtype of type 1 diabetes in Japanese children. To clarify the genetic background of IDDMS, we analyzed HLA-DRB1, -DQB1 and -DQA1 alleles, phenotypes, and genotypes and compared them with acute-onset type 1 diabetes, non-insulin-dependent diabetes mellitus (NIDDM), and control subjects. METHODS HLA-DRB1, -DQA1, and -DQB1 types were defined by DNA analysis using… CONTINUE READING

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