Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives.

@article{Schapira2014SlowingON,
  title={Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives.},
  author={Anthony H V Schapira and Charles W. Olanow and J Timothy Greenamyre and Erwan B{\'e}zard},
  journal={Lancet},
  year={2014},
  volume={384 9942},
  pages={545-55}
}
Several important advances have been made in our understanding of the pathways that lead to cell dysfunction and death in Parkinson's disease and Huntington's disease. These advances have been informed by both direct analysis of the post-mortem brain and by study of the biological consequences of the genetic causes of these diseases. Some of the pathways that have been implicated so far include mitochondrial dysfunction, oxidative stress, kinase pathways, calcium dysregulation, inflammation… CONTINUE READING